Gastroprotective effects of bromelain on indomethacin-induced gastric ulcer in rats

Gastric ulcer is one of the most common diseases gastrointestinal system and some its complications are main causes morbidity mortality. Bromelain (BRM), a sulfhydryl proteolytic enzyme, has multiple activities in many areas medicine as an antioxidant anti-inflammatory agent. In this study, it was aimed to investigate oxidative stress-mediated therapeutic effect BRM gastric model induced by indomethacin (IND) which non-steroidal drug (NSAID) with ulcer-forming effects. mucosal paraoxonase (PON), arylesterase (ARE), catalase (CAT), myeloperoxidase (MPO) glutathione peroxidase (GPx) activity total (GSH) levels were analyzed. Interleukin-33 (IL-33), nuclear factor erythroid 2-related 2 (Nrf2) heme oxygenase 1 (HO-1) determined immunohistochemically. Although IND-induced histopathological changes occurred, pretreatment prevented these As result that had anti-ulcerative at dose 50 mg/kg. given significantly decreased tissue MPO activity, increased CAT, PON, ARE, GPx GSH level. The IL-33 Nrf-2 HO-1 obtained IND group reversed BRM. result, concluded may have protective effects reducing inflammation regulating oxidant/antioxidant balance.